Taking bisphosphonates during pregnancy.
نویسندگان
چکیده
QUESTION Several of my female patients take bisphosphonates for low bone mineral density (BMD). Two of them are of reproductive age. Are these drugs safe during pregnancy? ANSWER Very little is currently known about the effects of bisphosphonates on human pregnancy. There have been only two reports of bisphosphonate use during late pregnancy. Animal studies suggest that biphosphonates cross the placenta and that the effect is an extension of the expected pharmacologic effect of bisphosphonates on both fetus and mother. Risks and benefits should be carefully weighed.
منابع مشابه
The use of bisphosphonates in women prior to or during pregnancy and lactation.
OBJECTIVE The unique pharmacokinetics of bisphosphonates (BPs) in conjunction with their use by an increasing number of women at reproductive age has raised serious concerns about their safety during pregnancy and lactation. Bisphosphonates cross the placenta. Animal studies have shown adverse effects on both the fetus and the mother, mostly at doses much higher than those commonly used in huma...
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ورودعنوان ژورنال:
- Canadian family physician Medecin de famille canadien
دوره 49 شماره
صفحات -
تاریخ انتشار 2003